APPL2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013670
Fusion event
HBV-APPL2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2735
Orient
+
Integrated sequence
ATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCC| |AAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGA
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
105625627/105231849 (Hg38)
End
105625627/105231849 (Hg38)
Orient
+
Location type
Intronic
Target gene
APPL2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-124-3p
Nearest miRNA
hsa-let-7i/Upstream/640133; hsa-mir-1178/Downstream/3403961;
Nearest TSS
ENST00000382841/Upstream/1989; ENST00000546866/Downstream/1305;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/123660, chr12-CpG: 69/Downstream/3870
Upstream sequence
TGGAAATGCAACTGTGATGCCCATTAGAACTGACAGGGAAACTCTGGTCTTCCCTTTTTAATTTAACTTGGCAGTGATCACCTCTGGAAAAAATATAACC
Downstream sequence
AGCTACCTTGGACACTGGCTATCCTCATTTACTATACTGTGTCTGCTCAAACTTTGGTTTGGAACAACAGAGATATTCTGAGACATAAAGAAGGAATGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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