Basic Information
VIS ID
TVIS10013671
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
End
105636638/105242860 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/651144; hsa-mir-1178/Downstream/3392950;
Nearby gene
APPL2(-6630) ; C12orf75(+87776) ;
Upstream sequence
TGTGGTCAATGAAattcagttctatgcatattaatgaagcatgtactttgttccaagcaccgaggtaggcactgcaggtttaataacgtaaaagaaacat
Downstream sequence
ggacttgctgcccttcaagggagattcccatctactaatggcagacgattaaaaacaGGAGTGTTCCAGTAGAGGACAATCCACATGACACAGGGAGCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate