Basic Information
VIS ID
TVIS10013673
Fusion event
HBV-LOC102724050 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
54751255/54357471 (Hg38)
End
54751255/54357471 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
LOC102724050
Nearest miRNA
hsa-mir-1244-3/Upstream/20157; hsa-let-7i/Downstream/2837033;
Nearest TSS
ENST00000382841/Upstream/3679; ENST00000548617/Downstream/7003;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/76267, chr12-CpG: 18/Downstream/11802
Nearby gene
COPZ1(-5622) ; GPR84(+4974) ;
Upstream sequence
TCTCCCTTATATTATGGACCTCCATCTTTGTTCACTACCCACCCAAACCCAGAACAAGCCCTTTCACTGGGTTGGGGGGTCACAGACACATGGCTTCTAG
Downstream sequence
AGCTGAGGGCTGCAGAAGGTATGTGGATCCATAGGCAGATCCACCACCCCTTCTCAATTTCCTGGAGGCCCAGAGCAAGGGATGTCAAGAAGTATTGGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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