Basic Information
VIS ID
TVIS10013676
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2545
Orient
+
Integrated sequence
CAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTT| |CCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTG
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
69525506/69491603 (Hg38)
End
69525506/69491603 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA16B
Nearest miRNA
hsa-mir-1225/Upstream/1258104; hsa-mir-11401/Downstream/74205;
Nearest TSS
ENST00000527434/Upstream/66754; ENST00000563474/Downstream/73491;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/66880, chr16-CpG: 131/Downstream/73931
Nearby gene
CYB5B(-25339) ; MIR1538(+74205) ;
Upstream sequence
TCTTCTTCAAAGCCTGTCCTTTCTGCAAAATTCTTAATCACTGTCTACCTCAGATGTCCTTTCTGTTTTTTCAGCATTTACCACTGGCTTACATGCTCAA
Downstream sequence
GTTTGTAttttatttttatttttattttttgaggcagggtcttgctttgttgcccaggctggagtgcagtggtgcaattaggactcactgcagcctcttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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