VISDB Viral Integration Site DataBase

VIS ID

TVIS10013678

Fusion event

HBV-EPB41L3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1883

Orient

-

Integrated sequence

TGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTG| |CCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTA

Chromosome

chr18

Cytoband

p11.31

Reference genome

Start

End

5439283/5439284 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-223-3p ; hsa-mir-877-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-1305 ; hsa-mir-498 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-627-3p ; hsa-mir-4275 ; hsa-mir-5697 ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-4524b-3p ; hsa-mir-7161-5p ; hsa-mir-548u

Nearest miRNA

hsa-mir-6718/Upstream/1553852; hsa-mir-1-2/Downstream/401411;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/142184, chr18-CpG: 129/Downstream/103564

Nearest cancer related gene

EPB41L3(TSG, No orient, 0)

Upstream sequence

CCAGGCTTCCACCCTGGAGGTCTTTCACCCATGCCTCACCCAGCGGCCACCGACTTGCCCTTACTCTAGGATTCTGACTTCACAGTCCACCCCTTATGCT

Downstream sequence

TCCAATACTCTCCCAAGACTTCCAAATCTCCCTGTCTCTCCATTAAATGACTTCTGGAAACTCCATTGCTCCATGAGCCCTTCCCAAACATTCAGAAGAA