Basic Information
VIS ID
TVIS10013679
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2406
Orient
+
Integrated sequence
AAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCT| |CAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACT
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
56118234/58451002 (Hg38)
End
56118234/58451002 (Hg38)
Orient
+
Location type
upstream;downstream
Fragile sites / regions
FRA18B
Target gene
MIR122 ; MIR3591
Nearest miRNA
hsa-mir-1-2/Upstream/2971704; hsa-mir-122/Downstream/72;
Nearest TSS
ENST00000575820/Upstream/4727; ENST00000622635/Downstream/25189;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/194166, chr18-CpG: 92/Downstream/219977
Nearest cancer related gene
MIR122(TSG, No orient, 0)
Upstream sequence
AAGCCTTTCATTGAGAGTGTTCAGCTCTTCCCATTGCTCAAGATGCTTGTACCCGTGATGCTTCTTTTCTCTGCTTAGGTCACAATATGTGGAGCTGACA
Downstream sequence
AGGTTCCCCTATTATCAGTGACAATGGTGGAATGTGGAGGTGAAGTTAACACCTTCGTGGCTACAGAGTTTCCTTAGCAGAGCTGTGGAGTGTGACAATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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