Basic Information
VIS ID
TVIS10013680
Fusion event
HBV-LOC643542 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1746
Orient
+
Integrated sequence
AGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGG| |GGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCT
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
65446707/67779470 (Hg38)
End
65446707/67779470 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA18C
Target gene
LOC643542
Nearest miRNA
hsa-mir-1-2/Upstream/697784; hsa-mir-548av/Downstream/5073851;
Nearest TSS
ENST00000575820/Upstream/103392; ENST00000580622/Downstream/35352;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/262734, chr18-CpG: 67/Downstream/935227
Upstream sequence
TTTGTTTGTTTATTTTGATGTAATTAATAAAAATAATTGAAGAAGCAGGATATGAACATGACTAAAAGCATGAAATTACAAAGCCCAAATTGATGAACTT
Downstream sequence
CTACACACTGGTGTATGTTATTGAAAGCCTTTGGATTCTGTTTGTTTTTACTTAGGCTGGAGCTCACTAAATTGTCAGTTTTCTTTTGATTCCCTGACCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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