Basic Information
VIS ID
TVIS10013688
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1907
Orient
+
Integrated sequence
CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA| |CATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCA
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
69219525/68992393 (Hg38)
End
69219525/68992393 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2E
Nearest miRNA
hsa-mir-1301/Upstream/2634065; hsa-mir-10b/Downstream/111289;
Nearest TSS
ENST00000437798/Upstream/17757; ENST00000481119/Downstream/20785;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/336951, chr2-CpG: 84/Downstream/20558
Nearby gene
GKN1(-11413) ; ANTXR1(+20751) ;
Nearest cancer related gene
GKN1(TSG, -11413) ;
Upstream sequence
CTTCCCTACATCAGCATGCTTCTCTTGCTTGGAACAAGTGTCAAAGCCCATCACACCCTGCACACCTATTACTCTTGAAAATCCTGATGTCATGGGCAGA
Downstream sequence
GTCAGACCTTGCCCAGGGGCAACTGCCTTCAATTCTGTCCTCTCCTTTTCTGAACACAGCAGTATTTGTGTTGGGGTAGAGGTCTCGCCAGAGGCACCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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