Basic Information
VIS ID
TVIS10013689
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1790
Orient
-
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
84188048/83960924 (Hg38)
End
84188048/83960924 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2L
Nearest miRNA
hsa-mir-1285-2/Upstream/4094341; hsa-mir-10b/Downstream/1822676;
Nearest TSS
ENST00000437798/Upstream/438110; ENST00000440495/Downstream/354184;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2493367, chr2-CpG: 27/Downstream/329666
Nearby gene
DHFRP3(-1103155) ; FUNDC2P2(+329758) ;
Upstream sequence
GGTATATATGGAAAGAGCTTtttttttagctttttttttttttttttttttttgagacggagtctcgctctgccgcccaggctggattgcagtggcacca
Downstream sequence
tcgctgttcactgcaacctctgcctcccgggttcaagcgattcccctgcctcagcctctctagtagccacgacgcccagctaattttttgtatttttagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate