Basic Information
VIS ID
TVIS10013693
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1925
Orient
+
Integrated sequence
TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA| |ATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCC
Host Sequence
Chromosome
chr6
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
63307043/62597138 (Hg38)
End
63307043/62597138 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/5206926; hsa-mir-10524/Downstream/8779822;
Nearest TSS
ENST00000381078/Upstream/310911; ENST00000370659/Downstream/614308;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/310815, chr6-CpG: 163/Downstream/975108
Nearby gene
KHDRBS2(-310943) ; LGSN(+678813) ;
Upstream sequence
GAGAGGTTGAGGACTGGGGACAGCAGGTTTGGAGTGGGGAGAAGCAGGGAAGGAGGTGAGTGCTCTATTTGGATATGCTGGGTCTGAGGCATCTGTGGAG
Downstream sequence
gttcccagggccattagagtcctatgagggtaaagagaaaaatcttccactacacttgaaactgtaatttcctcttgataattatgggttactcatgact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate