VISDB Viral Integration Site DataBase

VIS ID

TVIS10013694

Fusion event

HBV-UBE3C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

570

Orient

+

Integrated sequence

CGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGC| |TGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCT

Chromosome

chr7

Cytoband

q36.3

Reference genome

Start

End

156962722/157170028 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-let-7g-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-17-5p ; hsa-let-7a-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-30a-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-136-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-4297 ; hsa-mir-5581-5p ; hsa-mir-922 ; hsa-mir-3714 ; hsa-mir-532-5p ; hsa-mir-548an

Nearest miRNA

hsa-mir-10399/Upstream/5736389; hsa-mir-153-2/Downstream/404308;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/30362, chr7-CpG: 106/Downstream/109080

Nearest cancer related gene

UBE3C(OG, No orient, 0)

Upstream sequence

agtccgtctttttctgttgtttggaatagtttcagtaggaatagtaccagctcctcttgtacctctggtggaattcagctgtgaatgcatctggtcctgg

Downstream sequence

aggctggtcttgaactcctgacctcaggtgatccacctgccttggccccctgaagtgctgggattaaaggcatgagccaccatgcctggttttttttttt