Basic Information
VIS ID
TVIS10013697
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2153
Orient
+
Integrated sequence
ACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCT| |AGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAG
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
End
61479459/61085678 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1228/Upstream/3260986; hsa-let-7i/Downstream/1174681;
Nearby gene
SLC16A7(-1295824) ; TAFA2(+622570) ;
Upstream sequence
aatttgtgtttgtcaatcatacctcagtaaagctggaaaaaTTAATGTAAAATACATTTTTAAAAAAGGAAGATAAAAGAGAAGTCCAGAGTGAGGATCA
Downstream sequence
CATTATTCTTTGTTTATAAGAAAAAATTAGCATAAATCAGAAAATGTTTATTGTTAAATTAAATTCAATGAAAGCAAGATTTTTTATGCATCTTAGTAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate