Basic Information
VIS ID
TVIS10013698
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2380
Orient
+
Integrated sequence
CGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAA| |CTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGA
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
89298516/88904739 (Hg38)
End
89298516/88904739 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/2159590; hsa-mir-1178/Downstream/5657050;
Nearest TSS
ENST00000382841/Upstream/302877; ENST00000611513/Downstream/114940;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/323850, chr12-CpG: 248/Downstream/446652
Nearby gene
KITLG(-324266) ; LINC02458(+106387) ;
Upstream sequence
CAGAAAGATACATTCttacaaatgcattatatcattagtgctccaaaaatatccttttcaggtagggattattattatttccacatttcatatggtgaaa
Downstream sequence
ctgagttttaataagctgaaatgcgttgtccaaaatgtctcatgttaataCAATTAACAACAAAGATGGCCTAGAGTTAGAtcattccattcaccacaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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