Basic Information
VIS ID
TVIS10013699
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1783
Orient
-
Integrated sequence
GTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGC| |TGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTG
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
39150040/38857839 (Hg38)
End
39150040/38857839 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/1884938; hsa-mir-10393/Downstream/2833746;
Nearest TSS
ENST00000557528/Upstream/4407; ENST00000560709/Downstream/161394;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/292382, chr15-CpG: 109/Downstream/722487
Nearby gene
LINC02694(-157801) ; C15orf54(+392845) ;
Upstream sequence
GCTTTGGATGTAGATTTTAGAAATGAATCAACCGTTGTACAGTTTTGTTTCCCATCTCTTGCTATGCAGGCCAGTGTTATAAGTTTGATGCAGCTGAAGA
Downstream sequence
TGGTAGTGTTAGTTGGTGGCCCTTCAGAGATAATTCTTATGTCCCATCCCATGGAAGATAGAGAAGTATGGGAGATAAAACTGTGGGCTCTTTCTTCCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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