Basic Information
VIS ID
TVIS10013706
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2943
Orient
+
Integrated sequence
TACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATT| |GGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGG
Host Sequence
Chromosome
chr8
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
137386451/136374208 (Hg38)
End
137386451/136374208 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/1569263; hsa-mir-10400/Downstream/4358356;
Nearest TSS
ENST00000518652/Upstream/327161; ENST00000523232/Downstream/115240;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/916109, chr8-CpG: 119/Downstream/2122344
Nearby gene
KHDRBS3(-726603) ; FAM135B(+1755815) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
TCATTTGTTTCACTACaaattattttattattttattttttaCTGGTTTAGTCCAGAACTGTTCATGACAAACTCTTCTGTGTACTCACATAATTTTAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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