Basic Information
VIS ID
TVIS10013707
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1746
Orient
-
Integrated sequence
AGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGG| |GGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCT
Host Sequence
Chromosome
chr8
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
137394321/136382078 (Hg38)
End
137394321/136382078 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/1577133; hsa-mir-10400/Downstream/4350486;
Nearest TSS
ENST00000518652/Upstream/335031; ENST00000523232/Downstream/107370;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/923979, chr8-CpG: 119/Downstream/2114474
Nearby gene
KHDRBS3(-734473) ; FAM135B(+1747945) ;
Upstream sequence
acaaagatcaaaagagacaaagaaggccattacataatggtaaagggttcaatgcaacaagaagagctaactattctaacaatatatgcatccaatacca
Downstream sequence
gattccccacaagcACAACTGATGGCAAAGCCTCACAGAACATCTTCAGAGGgtattatatatgtgtgtatgtaatatttgtattatatatttgtgtatg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate