VISDB Viral Integration Site DataBase

VIS ID

TVIS10013710

Fusion event

HBV-HNF4A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2291

Orient

+

Integrated sequence

TCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCC| |AGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCT

Chromosome

chr20

Cytoband

q13.12

Reference genome

Start

End

42993435/44364795 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-34a-5p ; hsa-mir-197-3p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-766-3p ; hsa-mir-34b-5p ; hsa-mir-765 ; hsa-mir-629-5p ; hsa-mir-216a-5p ; hsa-mir-143-3p ; hsa-mir-4776-3p ; hsa-mir-6875-3p ; hsa-mir-3180-5p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-488-5p ; hsa-mir-24-1-5p

Nearest miRNA

hsa-mir-103a-2/Upstream/3195717; hsa-mir-1-1/Downstream/43325;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/37707, chr20-CpG: 37/Downstream/110971

Nearest cancer related gene

HNF4A(TSG, No orient, 0)

Upstream sequence

ctgacctcgtgatccacctgccccgacctcccaaagtgctggggttacaggtgtgagccaccgtgcccagccGGTCCTTCAATTTATTGGGATTATATTA

Downstream sequence

GTTCAGACAATATAGCTTATGTAACAAGCAAATGCAGACTTTAAGTTAGAAGTTTATTGACCTCTGTGGCATAGTCATCCAGGGACCCCTAAGGTCACCC