Basic Information
VIS ID
TVIS10013711
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1916
Orient
+
Integrated sequence
TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC| |TTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTAT
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
69911524/69445841 (Hg38)
End
69911524/69445841 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1C ; FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/1262231; hsa-mir-11399/Downstream/1621790;
Nearest TSS
ENST00000473358/Upstream/12586; ENST00000370958/Downstream/122557;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/948518, chr1-CpG: 131/Downstream/121443
Nearby gene
DEPDC1(-948725) ; LRRC7(+314334) ;
Upstream sequence
cccaagactaaaccaggaagaagttgaatctctgaatagaccaataacaggctctgaaattgaggcaataattaatagcttaccaacaaaaaaagtccgg
Downstream sequence
gaccagacggattcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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