Basic Information
VIS ID
TVIS10013715
Fusion event
HBV-ZNF37BP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
43024175/42528727 (Hg38)
End
43024175/42528727 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA10G
Target gene
ZNF37BP
Nearest miRNA
hsa-mir-1265/Upstream/6887475; hsa-mir-107/Downstream/468836;
Nearest TSS
ENST00000439456/Upstream/53099; ENST00000439913/Downstream/65940;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/51222, chr10-CpG: 67/Downstream/23409
Upstream sequence
atttttgcatcaatgttcatcaaggatattggtctaaaattctcttttttggttgtgtctctgcccggctttggtatcaggatgatgctggcctcataaa
Downstream sequence
gtgagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaacagttcttccttgtacccctggtagaattcagctgtgag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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