Basic Information
VIS ID
TVIS10013716
Fusion event
HBV-HECTD2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr10
Cytoband
q23.32
Reference genome
GRCh37/hg19
Start
93293035/91533278 (Hg38)
End
93293035/91533278 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10D
Target gene
HECTD2-AS1
Nearest miRNA
hsa-mir-107/Upstream/1940451; hsa-mir-1287/Downstream/4531037;
Nearest TSS
ENST00000439456/Upstream/49170; ENST00000371627/Downstream/99776;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/122462, chr10-CpG: 49/Downstream/99632
Upstream sequence
ttcacagccgaattctaccagaggtacaaggaggagctggtaccataccttctgaaactattccaatcaataggaaaagagggaatcctccctaactcat
Downstream sequence
tttatgaggccagcatcatcctgataccaaagcctggcagagacacaacaaaaaaagagaattttagaccaatatccctgatgaacatcgatgcaaaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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