VISDB Viral Integration Site DataBase

VIS ID

TVIS10013718

Fusion event

HBV-GUCY1A2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2069

Orient

+

Integrated sequence

TCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAG| |GCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTC

Chromosome

chr11

Cytoband

q22.3

Reference genome

Start

End

106669004/106798278 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-3619-3p ; hsa-mir-3917 ; hsa-mir-7705 ; hsa-mir-6512-5p ; hsa-mir-625-3p ; hsa-mir-145-3p ; hsa-mir-1288-5p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-330-3p

Nearest miRNA

hsa-mir-10392/Upstream/2948298; hsa-let-7a-2/Downstream/4549479;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/720189, chr11-CpG: 137/Downstream/219319

Upstream sequence

tcctggacacatacaccctcccaagactaaaccaggaagaagttgaatccctgaatagacccataacagggtctgaaattgaggcaatcattaatagcct

Downstream sequence

accaaccaaaaaaagtccaggaccagacggattcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatca