Basic Information
VIS ID
TVIS10013719
Fusion event
HBV-LINC02548 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1871
Orient
+
Integrated sequence
GTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGC| |CTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTC
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
13844124/13822577 (Hg38)
End
13844124/13822577 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02548
Nearest miRNA
hsa-mir-210/Upstream/1658810; hsa-let-7a-2/Downstream/2146956;
Nearest TSS
ENST00000527297/Upstream/37187; ENST00000591785/Downstream/48039;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/153400, chr11-CpG: 185/Downstream/139942
Nearby gene
FAR1(-90231) ; SPON1(+140060) ;
Upstream sequence
ttgtgtctctgccagcctttggtatcaggatgatgctgacctcataaaatgagttagggagtattccctctttttctattgattggaatagtttcagaag
Downstream sequence
gaatggtaccagctcctccttgtacctctggtagaattcggctgtgaatccgtctggtcctggactttttttggttggtaagctattaattattgcctca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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