Basic Information
VIS ID
TVIS10013723
Fusion event
HBV-ENPP7P8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1904
Orient
+
Integrated sequence
GCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT| |GGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCC
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71438210/71727164 (Hg38)
End
71438210/71727164 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
ENPP7P8
Nearest miRNA
hsa-mir-10392/Upstream/253596; hsa-let-7a-2/Downstream/345064;
Nearest TSS
ENST00000527297/Upstream/21760; ENST00000526393/Downstream/60346;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/87212, chr11-CpG: 121/Downstream/59361
Nearby gene
KRTAP5-11(-144289) ; FAM86C1(+60347) ;
Upstream sequence
caaataaactagaaaatctagaagaaatggataaattcctcgacacgtacaccctcccaaggctaaaccaggaagacgttgaatctctgaatagaccaat
Downstream sequence
aacaggctctgaaattgaggcaataattaatagcttaccaaccaaaaaaagtccaggaccagacggattcacagccgaattctaccagaggtacaaggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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