Basic Information
VIS ID
TVIS10013725
Fusion event
HBV-MIR4300HG integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1876
Orient
+
Integrated sequence
AGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCA| |AGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCC
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
82056174/82345132 (Hg38)
End
82056174/82345132 (Hg38)
Orient
+
Location type
Intronic
Target gene
MIR4300HG
Nearest miRNA
hsa-mir-10392/Upstream/454296; hsa-let-7a-2/Downstream/3933201;
Nearest TSS
ENST00000527297/Upstream/245089; ENST00000526305/Downstream/58781;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2903972, chr11-CpG: 25/Downstream/344411
Nearby gene
MIR4300(-454296) ; FAM181B(+386872) ;
Upstream sequence
cctcgacacatacatcctcccaagactaaaccaggaagaagttgaatctctgaatagaccaataacaggctctgaaattgaggcaataattaatagctta
Downstream sequence
ccaaccaaaaaaagtccaggaccagacggattcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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