Basic Information
VIS ID
TVIS10013729
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
23545557/23392623 (Hg38)
End
23545557/23392623 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/5719229; hsa-let-7i/Downstream/819798;
Nearest TSS
ENST00000382841/Upstream/141124; ENST00000546118/Downstream/191989;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/767344, chr12-CpG: 92/Downstream/1169399
Nearby gene
ETNK1(-701949) ; SOX5(+139674) ;
Upstream sequence
cacagccaaattctaccagaggtacaaaaaggagctaatactattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcactt
Downstream sequence
tatgaggccagcatcatcctgataccaaagcgaggcagagacaaaacaaaaaaggagaatttttgaccaatgtccctgatgaacatcgatgcaaaaatcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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