VISDB Viral Integration Site DataBase

VIS ID

TVIS10013733

Fusion event

HBV-SLC11A2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1859

Orient

+

Integrated sequence

TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG

Chromosome

chr12

Cytoband

q13.12

Reference genome

Start

End

51369920/50976137 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7d-5p ; hsa-mir-374b-5p ; hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-122-5p ; hsa-mir-218-5p ; hsa-mir-24-3p ; hsa-mir-16-5p ; hsa-mir-548c-3p ; hsa-mir-155-5p ; hsa-mir-203b-3p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-4451 ; hsa-mir-6825-5p ; hsa-mir-6799-5p ; hsa-mir-655-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-4655-5p ; hsa-mir-1537-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-550a-3p ; hsa-mir-200c-5p ; hsa-mir-196a-3p ; hsa-mir-661 ; hsa-mir-4696 ; hsa-mir-4725-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-766-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-939-3p ; hsa-mir-339-5p ; hsa-mir-6849-3p ; hsa-mir-6501-3p ; hsa-mir-451b ; hsa-mir-508-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-3667-5p ; hsa-mir-7703 ; hsa-mir-4793-3p ; hsa-mir-1273g-3p ; hsa-mir-665 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4736 ; hsa-mir-7160-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-5694 ; hsa-mir-383-5p ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-6771-3p

Nearest miRNA

hsa-mir-1244-3/Upstream/741925; hsa-let-7i/Downstream/1922752;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/132996, chr12-CpG: 73/Downstream/49720

Nearby gene

HIGD1C(-5631) ; SLC11A2(+3646) ;

Upstream sequence

ttcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcat

Downstream sequence

tttatgaggccaacatcatcctgataccaaagcctagcagagacacaacaaaaaaagagaattttagaccaatatccctgatgaacattgatgcaaaaat