Basic Information
VIS ID
TVIS10013736
Fusion event
HBV-LOC728755 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
27829265/27360059 (Hg38)
End
27829265/27360059 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC728755
Nearest miRNA
hsa-mir-208a/Upstream/451334; hsa-mir-1185-1/Downstream/273146;
Nearest TSS
ENST00000550708/Upstream/486896; ENST00000555350/Downstream/252529;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1154787, chr14-CpG: 203/Downstream/1405624
Nearby gene
MIR4307(-451334) ; LINC00645(+252529) ;
Upstream sequence
ttttgcatcgaggttcatcagggatattggtctaaaattctttatttttttgttgtgtctctgccaggctttgggatcaggatgatgttggcctcataaa
Downstream sequence
gtgagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagctcctccttgtacctctggtagaattctactatgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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