Basic Information
VIS ID
TVIS10013737
Fusion event
HBV-LOC400464 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
100370674/99830469 (Hg38)
End
100370674/99830469 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC400464
Nearest miRNA
hsa-mir-10393/Upstream/1045967; hsa-mir-1302-10/Downstream/2129990;
Nearest TSS
ENST00000557528/Upstream/22481; ENST00000622345/Downstream/8161;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/23220, chr15-CpG: 297/Downstream/95806
Nearby gene
DNM1P46(-23542) ; ADAMTS17(+140969) ;
Upstream sequence
atttttgcgttgatgttcttcagggatattggtctaaaattctctttttttgttgtgtctctgccaggctttggtatcaggatgatgctggcttcataaa
Downstream sequence
gtgagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagctcctccttgtacctctggtagaattcggctgtgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate