VISDB Viral Integration Site DataBase

VIS ID

TVIS10013743

Fusion event

HBV-AMFR integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1859

Orient

+

Integrated sequence

TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG

Chromosome

chr16

Cytoband

q13

Reference genome

Start

End

56429086/56395174 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-376a-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-6875-3p ; hsa-mir-607 ; hsa-mir-186-3p ; hsa-mir-4759 ; hsa-mir-140-3p ; hsa-mir-505-3p ; hsa-mir-1197 ; hsa-mir-1233-5p ; hsa-mir-20a-3p ; hsa-mir-3664-3p ; hsa-mir-3934-3p ; hsa-mir-4265 ; hsa-mir-4296 ; hsa-mir-4322 ; hsa-mir-4436a ; hsa-mir-4648 ; hsa-mir-4654 ; hsa-mir-4769-5p ; hsa-mir-5000-3p ; hsa-mir-6759-5p ; hsa-mir-6778-5p ; hsa-mir-6796-5p

Nearest miRNA

hsa-mir-1225/Upstream/149551; hsa-mir-11401/Downstream/463344;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/31060, chr16-CpG: 111/Downstream/29590

Upstream sequence

ttcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcat

Downstream sequence

tttatgaggccagcatcatcctgataccaaagctgggcagagacacaacaaaaaaagagaattttagaccaatatccctgatgaacatcgatgcaaaaat