Basic Information
VIS ID
TVIS10013745
Fusion event
HBV-LINC02141 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
60014007/59980103 (Hg38)
End
60014007/59980103 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02141
Nearest miRNA
hsa-mir-1225/Upstream/2207751; hsa-mir-11401/Downstream/7222218;
Nearest TSS
ENST00000527434/Upstream/124750; ENST00000565506/Downstream/379377;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/224935, chr16-CpG: 117/Downstream/2055114
Nearby gene
APOOP5(-224912) ; CDH8(+1671908) ;
Upstream sequence
ttcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcat
Downstream sequence
tttatgaggccagcatcattctgataccaaagccaggaagagacacaaccaaaaaagagaattttagaccaatatccttgatgaacattgatgcaaaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate