Basic Information
VIS ID
TVIS10013746
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
85908703/85875097 (Hg38)
End
85908703/85875097 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12128/Upstream/133397; hsa-mir-11401/Downstream/43250;
Nearest TSS
ENST00000527434/Upstream/70028; ENST00000565552/Downstream/23706;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/45102, chr16-CpG: 100/Downstream/23418
Nearby gene
COX4I1(-68096) ; IRF8(+24071) ;
Nearest cancer related gene
IRF8(TSG, +24071) ;
Upstream sequence
tttgaatcaatgttcgtcagggatattggtctaaaattctcttttttttgttgtgtctctgcccggctttggtatcaggatgatgctggcctcataaaat
Downstream sequence
gagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagctcctccttgtacctctggtagaattcggctgtgaatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate