Basic Information
VIS ID
TVIS10013752
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1873
Orient
+
Integrated sequence
ACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCT| |CCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTT
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
56783255/59116023 (Hg38)
End
56783255/59116023 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA18B
Nearest miRNA
hsa-mir-1-2/Upstream/664865; hsa-mir-5011/Downstream/7965561;
Nearest TSS
ENST00000575820/Upstream/32268; ENST00000593132/Downstream/23454;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/251908, chr18-CpG: 69/Downstream/23353
Nearby gene
OACYLP(-62809) ; SEC11C(+23870) ;
Upstream sequence
acacatacatcctcccaagactaaaccaggaagaagttgaatctctaaatagaccgataacaggctctgaaattgaggcgataaataatagcctaccaac
Downstream sequence
caaaaaaagtccaggaccagacggattcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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