Basic Information
VIS ID
TVIS10013754
Fusion event
HBV-LOC105372326 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1862
Orient
+
Integrated sequence
AAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTAC| |TGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCT
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
22079398/21896596 (Hg38)
End
22079398/21896596 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105372326
Nearest miRNA
hsa-mir-10395/Upstream/1497242; hsa-let-7e/Downstream/13226104;
Nearest TSS
ENST00000633603/Upstream/44471; ENST00000596471/Downstream/92312;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/44455, chr19-CpG: 23/Downstream/44254
Nearby gene
ZNF43(-44528) ; ZNF208(+69499) ;
Upstream sequence
ctctttttctattgattggaatagtttcagaaggaacggtaccagctcctctttgtaactctggtagaattcagctgtgaatccatctggtcctggactt
Downstream sequence
ttttttggttggtaagctattaattattgcctcaatttcagagcctgttattgatctattcagagattcaacttcttcctggtttagtcttgggagggtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate