Basic Information
VIS ID
TVIS10013757
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1895
Orient
+
Integrated sequence
TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT| |TTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTA
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43221850/42717698 (Hg38)
End
43221850/42717698 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-mir-10395/Upstream/366493; hsa-let-7e/Downstream/1935988;
Nearest TSS
ENST00000633603/Upstream/122643; ENST00000425668/Downstream/21674;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/19537, chr19-CpG: 42/Downstream/690317
Nearby gene
CEACAM8(-122768) ; PSG3(+3944) ;
Upstream sequence
accaggaacaagttgaatctgtgaatagaccaataacaggatctgaaattgtggcaataatcaatagcttaccaaccaaaaagagtccaggaccagatgg
Downstream sequence
attcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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