VISDB Viral Integration Site DataBase

VIS ID

TVIS10013758

Fusion event

HBV-ZRANB3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1859

Orient

+

Integrated sequence

TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG

Chromosome

chr2

Cytoband

q21.3

Reference genome

Start

End

135993004/135235434 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2F

Target gene

miRNAs that regulate target gene

hsa-mir-6855-5p ; hsa-mir-5096 ; hsa-mir-3170 ; hsa-mir-4662a-5p ; hsa-mir-193b-5p ; hsa-mir-6890-5p ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p

Nearest miRNA

hsa-mir-1285-2/Upstream/377561; hsa-mir-10b/Downstream/429963;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/182746, chr2-CpG: 36/Downstream/295966

Upstream sequence

cacagccaaattctacgagaggtacaaggaagagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcactt

Downstream sequence

tatgaggccagcatcatcctgataccaaagcctggcagagacacaacaaaaaaagagaattttagaccaatatccctgatgaacattgatgcaaaaatcc