Basic Information
VIS ID
TVIS10013761
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
75199743/74972616 (Hg38)
End
75199743/74972616 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2E
Nearest miRNA
hsa-mir-1285-2/Upstream/4719611; hsa-mir-10b/Downstream/118196;
Nearest TSS
ENST00000437798/Upstream/13505; ENST00000604271/Downstream/148150;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/13566, chr2-CpG: 96/Downstream/226850
Nearby gene
POLE4(-2884) ; TACR1(+73847) ;
Upstream sequence
atttttgcatcaatgttcatcagggatattggtctaaaattctcttttttggttgtgtctctgcctggctttggtatcaggatgatgctggcctcatcaa
Downstream sequence
gtgagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagttcctccttgtacctctggttgaattcagctgtgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate