Basic Information
VIS ID
TVIS10013762
Fusion event
HBV-ADGRG7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr3
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
100406742/100687898 (Hg38)
End
100406742/100687898 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRG7
miRNAs that regulate target gene
hsa-mir-1297 ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-3121-3p ; hsa-mir-4465 ; hsa-mir-4762-5p ; hsa-mir-5697
Nearest miRNA
hsa-let-7g/Upstream/723500; hsa-mir-12124/Downstream/2836135;
Nearest TSS
ENST00000440867/Upstream/33702; ENST00000479672/Downstream/21433;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/195167, chr3-CpG: 72/Downstream/21327
Upstream sequence
AAATGCTAATGTTGAAATGGAATCCAGAAAGGTAAATGAGAAGAAGAAACAGTATGACTATGCTTAGTAAATTTATGTGTATGTATCAGTGGCATTGTAT
Downstream sequence
gttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagctcctccttgtacctctggtagaattcggctgtgaatcca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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