Basic Information
VIS ID
TVIS10013765
Fusion event
HBV-LINC02046 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1903
Orient
+
Integrated sequence
CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA| |TGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGC
Host Sequence
Chromosome
chr3
Cytoband
q24
Reference genome
GRCh37/hg19
Start
148068472/148350685 (Hg38)
End
148068472/148350685 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02046
Nearest miRNA
hsa-let-7g/Upstream/13912779; hsa-mir-1224/Downstream/3215191;
Nearest TSS
ENST00000440867/Upstream/38538; ENST00000475166/Downstream/347099;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/926081, chr3-CpG: 56/Downstream/346970
Nearby gene
ZIC1(-933966) ; AGTR1(+347186) ;
Upstream sequence
ATAGcagcacttctcagactttaatgtacgtgtgatcatccaggcaccttgccaaattgcagactctggctcagactctctggggtggaatctgagtctg
Downstream sequence
tcccaagactaaaccaggaagaagttgaatctctgaatagatcaataacaggctctgaaattgaggcaataattaatagcttaccaaccaaaaaaagtcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate