Basic Information
VIS ID
TVIS10013766
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
154314386/154596597 (Hg38)
End
154314386/154596597 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA3D
Nearest miRNA
hsa-let-7g/Upstream/3030602; hsa-mir-1224/Downstream/4686049;
Nearest TSS
ENST00000440867/Upstream/57288; ENST00000497890/Downstream/264420;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/167421, chr3-CpG: 60/Downstream/483012
Nearby gene
GPR149(-166882) ; MME(+483050) ;
Nearest cancer related gene
MME(TSG, +483050) ;
Upstream sequence
agcctccagctctatccatgttcccgcaaaaggcatcacctcattcttatttatggctgcatagtattccatcgtgtatatgtaccacattttctttagt
Downstream sequence
gtgagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagttcctccttgtacttctggtagaattcggctttgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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