VISDB Viral Integration Site DataBase

VIS ID

TVIS10013768

Fusion event

HBV-PPM1L integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1895

Orient

+

Integrated sequence

TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT| |TTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTA

Chromosome

chr3

Cytoband

q26.1

Reference genome

Start

End

160764244/161046456 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-4728-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6721-5p ; hsa-mir-6731-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-4722-5p ; hsa-mir-3616-3p ; hsa-mir-6823-5p ; hsa-mir-4459 ; hsa-mir-3619-5p ; hsa-mir-761 ; hsa-mir-214-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-4779 ; hsa-mir-6165 ; hsa-mir-665 ; hsa-mir-3650 ; hsa-mir-7160-5p ; hsa-mir-3934-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4790-3p ; hsa-mir-767-3p ; hsa-mir-4649-3p ; hsa-mir-3664-3p ; hsa-mir-4433a-3p ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-6893-5p ; hsa-mir-940 ; hsa-mir-6808-5p ; hsa-mir-4695-5p ; hsa-mir-490-3p ; hsa-mir-6809-5p ; hsa-mir-31-5p ; hsa-mir-550b-3p ; hsa-mir-4501 ; hsa-mir-34c-3p ; hsa-mir-216a-5p ; hsa-mir-182-5p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-138-2-3p ; hsa-mir-186-3p ; hsa-mir-103b ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-8056 ; hsa-mir-7977 ; hsa-mir-3165 ; hsa-mir-6880-5p ; hsa-mir-8071 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-138-5p ; hsa-mir-4456 ; hsa-mir-342-3p ; hsa-mir-383-3p ; hsa-mir-1228-3p

Nearest miRNA

hsa-let-7g/Upstream/641631; hsa-mir-1224/Downstream/3125015;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/289757, chr3-CpG: 85/Downstream/58250

Nearest cancer related gene

PPM1L(TSG, No orient, 0)

Upstream sequence

ttagtGATACATAATACATCAGGTTTTCCCTGGCAATACCAAAATCACTGGTATATAATTGATGCAAATTAATTACTAGTGTGTAATTAAAATAAATTTC

Downstream sequence

aaccaaaaaaagtccaggaccagacggattcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaata