Basic Information
VIS ID
TVIS10013769
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1040
Orient
+
Integrated sequence
AGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGT| |GGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGA
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
192952816/193235027 (Hg38)
End
192952816/193235027 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/3405018; hsa-mir-3137/Downstream/1899479;
Nearest TSS
ENST00000440867/Upstream/58163; ENST00000264735/Downstream/6098;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/316849, chr3-CpG: 84/Downstream/5893
Nearby gene
MB21D2(-316866) ; PLAAT1(+6101) ;
Upstream sequence
CAGGTTTTCCCTGGCAATACCAAAATCACTGGTATATAATTGATGCAAATTAATTACTAGTGTGTAATTAAAATAAATTTCATCTGGATTTTATTAAGAT
Downstream sequence
gtaatgattttagattttattttgaaagacatacgaaattattggaagattttgagcaggggagcaacatgctatacattttttttttttgagatgggat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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