Basic Information
VIS ID
TVIS10013773
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr3
Cytoband
p26.1
Reference genome
GRCh37/hg19
Start
6311117/6269430 (Hg38)
End
6311117/6269430 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-4790/Upstream/1019175; hsa-let-7g/Downstream/4010921;
Nearest TSS
ENST00000440867/Upstream/120946; ENST00000414603/Downstream/221049;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1080925, chr3-CpG: 71/Downstream/591706
Nearby gene
MIR4790(-1019177) ; GRM7(+591685) ;
Upstream sequence
ggggtttcaccatcttggccagactggtcttgaactcctgacctcatgatccacccgccttggcctcccaaagtgctgggattacaggcgtgagccgtca
Downstream sequence
gtgagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagttcctccttgtacctctggtagaattcggttgtgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate