VISDB Viral Integration Site DataBase

VIS ID

TVIS10013776

Fusion event

HBV-CD38 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2895

Orient

+

Integrated sequence

CACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCG| |ACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGC

Chromosome

chr4

Cytoband

p15.32

Reference genome

Start

End

15840797/15839174 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-140-3p ; hsa-mir-659-3p ; hsa-mir-4776-3p ; hsa-mir-218-1-3p ; hsa-mir-4659b-5p ; hsa-mir-5590-5p ; hsa-mir-4659a-5p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-1273g-5p ; hsa-mir-203a-5p ; hsa-mir-3613-3p ; hsa-mir-5692a

Nearest miRNA

hsa-mir-12113/Upstream/2211217; hsa-mir-12115/Downstream/4689101;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/60068, chr4-CpG: 130/Downstream/243398

Upstream sequence

tgatgtctgtagttttctcttgttcttttttttagacggagtcttgctctgtctcccaggctggagtgcagtggtataatcttggctcactgcaatctct

Downstream sequence

TTTTTGGGTAAAAGCATTAACATTTCAGAATTTTATGATCTAATATTATGGTTCAAGCACTTGAAACAGGAGTGTCAGTTGTCAGAGACTAACAGGGAAG