Basic Information
VIS ID
TVIS10013779
Fusion event
HBV-LINC01612 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr4
Cytoband
q33
Reference genome
GRCh37/hg19
Start
171186949/170265798 (Hg38)
End
171186949/170265798 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01612
Nearest miRNA
hsa-mir-12113/Upstream/4879461; hsa-mir-1305/Downstream/920386;
Nearest TSS
ENST00000502981/Upstream/174099; ENST00000504509/Downstream/8121;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/175446, chr4-CpG: 117/Downstream/1546785
Nearby gene
AADAT(-175577) ; HSP90AA6P(+315672) ;
Upstream sequence
GCTACAGTATCTGTTAGCCGTCAACACTGCCATCCAGGTATACACTCACCTGTGCCAACCACTTCTTTTATTTTTTTTTTCCTGTTCCATGGAGTCAGTT
Downstream sequence
gtgagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagctcctccttgtacctctgatagaatttggctgtgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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