Basic Information
VIS ID
TVIS10013784
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr4
Cytoband
q23
Reference genome
GRCh37/hg19
Start
99648051/98726900 (Hg38)
End
99648051/98726900 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/11426317; hsa-mir-1243/Downstream/270487;
Nearest TSS
ENST00000502981/Upstream/67996; ENST00000583654/Downstream/163998;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/67891, chr4-CpG: 102/Downstream/201254
Nearby gene
TSPAN5(-68239) ; EIF4E(+151556) ;
Nearest cancer related gene
EIF4E(OG, +151556) ;
Upstream sequence
TAATTGGACAATTAAGCTCCCTCTTTAGACCTTTTGCTCTTATTATGTACAAATTTACCCCATCTCAAGAAGCATGAGACAGCTCCCCTGGAGTAAAAAT
Downstream sequence
ctcattttatgagaccagcatcaacctgatactaaagtctggcagagacacaacaaaaaaagagaattttagaccaatatccctgatgaacattgacgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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