Basic Information
VIS ID
TVIS10013786
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
125073066/125737373 (Hg38)
End
125073066/125737373 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/6582657; hsa-mir-103a-1/Downstream/3360315;
Nearest TSS
ENST00000502646/Upstream/244112; ENST00000507428/Downstream/442204;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1085318, chr5-CpG: 30/Downstream/685982
Nearby gene
ZNF608(-992261) ; GRAMD2B(+622722) ;
Upstream sequence
GGTCACATCCCGCCCGCACAGGGTGGAGGGCAACCTCGGGGTCCAGGCACCTGGCTCCAAGCCTCGGACTGCAGAGCTAGGAGGCCCGACTTCCAGCCCA
Downstream sequence
gagttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagctcctccttgtacctctggtagaattcggctgtgaatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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