Basic Information
VIS ID
TVIS10013790
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
97330655/97994951 (Hg38)
End
97330655/97994951 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5B
Nearest miRNA
hsa-mir-10397/Upstream/1915739; hsa-mir-103a-1/Downstream/2821531;
Nearest TSS
ENST00000502646/Upstream/113523; ENST00000505265/Downstream/166242;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/811010, chr5-CpG: 135/Downstream/773923
Nearby gene
RIOK2(-811650) ; RGMB(+774344) ;
Upstream sequence
ccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccct
Downstream sequence
tttatgaggccagcatcatcctgataccaaagccgggcagagacacaaccaaaaaagagaattttagaccaatatccctggtgaacattgatgcaaaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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