Basic Information
VIS ID
TVIS10013791
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
117569427/117248264 (Hg38)
End
117569427/117248264 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/10464044; hsa-mir-1202/Downstream/1820783;
Nearest TSS
ENST00000381078/Upstream/363475; ENST00000326274/Downstream/17294;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/370722, chr6-CpG: 21/Downstream/15157
Nearby gene
RFX6(-316101) ; VGLL2(+17294) ;
Upstream sequence
CATGAAGTTTTGGGAAAAGGTAAGTGCTGCAAGTAATATTTAATACTCCAACATTATTATCAACCATGAGGCTTGTGTATCAATTGATATATAAGCAGAA
Downstream sequence
tatgaggccagcatcattctgataccaaagccaggcagagacacaacaaaaaaagaaaattttagaccaatatcgttgatgaacattgatgcaaaaatcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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