NKAIN2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013792
Fusion event
HBV-NKAIN2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
125129277/124808131 (Hg38)
End
125129277/124808131 (Hg38)
Orient
+
Location type
Intronic
Target gene
NKAIN2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/4792874; hsa-mir-1202/Downstream/1676500;
Nearest TSS
ENST00000381078/Upstream/525127; ENST00000640160/Downstream/10268;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1003967, chr6-CpG: 128/Downstream/153847
Upstream sequence
tgtgtcctgaaaattttggtgttgaaccttaatgatcaatgtaataattttaagaggtggggcctttaagaggtgattagaccttgagggattccccttt
Downstream sequence
tatgaggccagcatcatcctgataccaaagccaggcagagacacaaccaaaaaagagaattttagaccaatatccttgatgaacattgatgcaaaaatcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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