Basic Information
VIS ID
TVIS10013798
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr7
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
116014937/116374883 (Hg38)
End
116014937/116374883 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7G
Nearest miRNA
hsa-mir-10525/Upstream/1721428; hsa-mir-10399/Downstream/645328;
Nearest TSS
ENST00000635602/Upstream/46987; ENST00000393480/Downstream/90393;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/163909, chr7-CpG: 94/Downstream/124602
Nearby gene
TES(-116100) ; CAV2(+124718) ;
Nearest cancer related gene
TES(TSG, -116100) ;
Upstream sequence
taatttccttaagttttggaggaacaggtggtattcggttacataaattctttagtaaggatttttgagattttggtatacccatcacataataaacact
Downstream sequence
tatgaggccagcatcatcctgataccaaagccgggcagagacacaacaaaaaaagagaattttagaccaatatccttgatgaacattgatgcaaaaatcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate